Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

BACKGROUND AND PURPOSE: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant‐like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microg...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Xu, Xiang, Piao, Hu‐Nan, Aosai, Fumie, Zeng, Xiao‐Yu, Cheng, Jia‐Hui, Cui, Yue‐Xian, Li, Jing, Ma, Juan, Piao, Hu‐Ri, Jin, Xuejun, Piao, Lian‐Xun
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589024/
https://ncbi.nlm.nih.gov/pubmed/32964428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15261
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