Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

BACKGROUND AND PURPOSE: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant‐like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microg...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Xu, Xiang, Piao, Hu‐Nan, Aosai, Fumie, Zeng, Xiao‐Yu, Cheng, Jia‐Hui, Cui, Yue‐Xian, Li, Jing, Ma, Juan, Piao, Hu‐Ri, Jin, Xuejun, Piao, Lian‐Xun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589024/
https://ncbi.nlm.nih.gov/pubmed/32964428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15261
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