Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

The tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolically converted to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a reaction which is both stereoselective and reversible. NNAL is also a lung carcinogen, with both (R)-NNAL and (S)-NNAL ind...

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Bibliografiske detaljer
Udgivet i:Mutagenesis
Main Authors: Ma, Bin, Zarth, Adam T, Carlson, Erik S, Villalta, Peter W, Stepanov, Irina, Hecht, Stephen S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Original Manuscripts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5907908/
https://ncbi.nlm.nih.gov/pubmed/29186507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gex031
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