A Shared Epitope of Collagen Type XI and Type II Is Recognized by Pathogenic Antibodies in Mice and Humans with Arthritis

BACKGROUND: Collagen XI (CXI) is a heterotrimeric molecule with triple helical structure in which the α3(XI) chain is identical to the α1(II) chain of collagen II (CII), but with extensive posttranslational modifications. CXI molecules are intermingled in the cartilage collagen fibers, which are mai...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Tong, Dongmei, Lönnblom, Erik, Yau, Anthony C. Y., Nandakumar, Kutty Selva, Liang, Bibo, Ge, Changrong, Viljanen, Johan, Li, Lei, Bãlan, Mirela, Klareskog, Lars, Chagin, Andrei S., Gjertsson, Inger, Kihlberg, Jan, Zhao, Ming, Holmdahl, Rikard
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906551/
https://ncbi.nlm.nih.gov/pubmed/29706949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00451
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