β-catenin and IL-1β dependent CXCL10 production drives progression of disease in a mouse model of Congenital Hepatic Fibrosis

Congenital Hepatic Fibrosis (CHF), a genetic disease caused by mutations in the PKHD1 gene, encoding for the protein fibrocystin (FPC), is characterized by biliary dysgenesis, progressive portal fibrosis, and by a PKA-mediated activating phosphorylation of β-Catenin at Ser675. Biliary structures of...

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Bibliographic Details
Published in:Hepatology
Main Authors: Kaffe, Eleanna, Fiorotto, Romina, Pellegrino, Francesca, Mariotti, Valeria, Amenduni, Mariangela, Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario, Spirli, Carlo
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906178/
https://ncbi.nlm.nih.gov/pubmed/29140564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29652
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