β-catenin and IL-1β dependent CXCL10 production drives progression of disease in a mouse model of Congenital Hepatic Fibrosis

Congenital Hepatic Fibrosis (CHF), a genetic disease caused by mutations in the PKHD1 gene, encoding for the protein fibrocystin (FPC), is characterized by biliary dysgenesis, progressive portal fibrosis, and by a PKA-mediated activating phosphorylation of β-Catenin at Ser675. Biliary structures of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Hepatology
Hlavní autoři: Kaffe, Eleanna, Fiorotto, Romina, Pellegrino, Francesca, Mariotti, Valeria, Amenduni, Mariangela, Cadamuro, Massimiliano, Fabris, Luca, Strazzabosco, Mario, Spirli, Carlo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906178/
https://ncbi.nlm.nih.gov/pubmed/29140564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29652
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky