Src kinase inhibition reduces inflammatory and cytoskeletal changes in ΔF508 human cholangiocytes and improves CFTR correctors efficacy

CFTR, the channel mutated in cystic fibrosis (CF), is expressed by the biliary epithelium (i.e cholangiocytes) of the liver. Progressive clinical liver disease (CFLD) occurs in about 10% of CF patients and represents the third leading cause of death. Impaired secretion and inflammation contribute to...

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Vydáno v:Hepatology
Hlavní autoři: Fiorotto, Romina, Amenduni, Mariangela, Mariotti, Valeria, Fabris, Luca, Spirli, Carlo, Strazzabosco, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5783790/
https://ncbi.nlm.nih.gov/pubmed/28836688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29400
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