Enhancing Understanding of the Visual Cycle by Applying CRISPR/Cas9 Gene Editing in Zebrafish

During the vertebrate visual cycle, all-trans-retinal is exported from photoreceptors to the adjacent RPE or Müller glia wherein 11-cis-retinal is regenerated. The 11-cis chromophore is returned to photoreceptors, forming light-sensitive visual pigments with opsin GPCRs. Dysfunction of this process...

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Bibliografiska uppgifter
I publikationen:Front Cell Dev Biol
Huvudupphovsmän: Ward, Rebecca, Sundaramurthi, Husvinee, Di Giacomo, Valeria, Kennedy, Breandán N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2018
Ämnen:
Cell and Developmental Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5904205/
https://ncbi.nlm.nih.gov/pubmed/29696141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2018.00037
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