Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F(0) animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of gen...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Naert, Thomas, Tulkens, Dieter, Edwards, Nicole A., Carron, Marjolein, Shaidani, Nikko-Ideen, Wlizla, Marcin, Boel, Annekatrien, Demuynck, Suzan, Horb, Marko E., Coucke, Paul, Willaert, Andy, Zorn, Aaron M., Vleminckx, Kris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473854/
https://ncbi.nlm.nih.gov/pubmed/32887910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71412-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados