Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

CRISPR/Cas9 genome editing has revolutionized functional genomics in vertebrates. However, CRISPR/Cas9 edited F(0) animals too often demonstrate variable phenotypic penetrance due to the mosaic nature of editing outcomes after double strand break (DSB) repair. Even with high efficiency levels of gen...

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Publicat a:Sci Rep
Autors principals: Naert, Thomas, Tulkens, Dieter, Edwards, Nicole A., Carron, Marjolein, Shaidani, Nikko-Ideen, Wlizla, Marcin, Boel, Annekatrien, Demuynck, Suzan, Horb, Marko E., Coucke, Paul, Willaert, Andy, Zorn, Aaron M., Vleminckx, Kris
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7473854/
https://ncbi.nlm.nih.gov/pubmed/32887910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71412-0
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