Phase I Dose Escalation Multicenter Trial of Pracinostat Alone and in Combination with Azacitidine in Patients with Advanced Hematologic Malignancies

BACKGROUND: Pracinostat is a potent histone deacetylase inhibitor with antitumor activity in both solid tumor and acute myeloid leukemia (AML) cell lines. Pracinostat has modest clinical activity in advanced solid tumors. Given the higher preclinical sensitivity of hematologic malignancies to pracin...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer
Autori principali: Abaza, Yasmin, Kadia, Tapan, Jabbour, Elias, Konopleva, Marina, Borthakur, Gautam, Ferrajoli, Alessandra, Estrov, Zeev, Wierda, William, Alfonso, Ana, Chong, Toh Han, Chuah, Charles, Koh, Liang-Piu, Goh, Boon-Cher, Chang, Julie E., Durkes, Daniel, Foudray, Maria Cielo, Kantarjian, Hagop, Dong, Xiao Qin, Garcia-Manero, Guillermo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901648/
https://ncbi.nlm.nih.gov/pubmed/28841236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30949
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi