Phase I Dose Escalation Multicenter Trial of Pracinostat Alone and in Combination with Azacitidine in Patients with Advanced Hematologic Malignancies

BACKGROUND: Pracinostat is a potent histone deacetylase inhibitor with antitumor activity in both solid tumor and acute myeloid leukemia (AML) cell lines. Pracinostat has modest clinical activity in advanced solid tumors. Given the higher preclinical sensitivity of hematologic malignancies to pracin...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer
Main Authors: Abaza, Yasmin, Kadia, Tapan, Jabbour, Elias, Konopleva, Marina, Borthakur, Gautam, Ferrajoli, Alessandra, Estrov, Zeev, Wierda, William, Alfonso, Ana, Chong, Toh Han, Chuah, Charles, Koh, Liang-Piu, Goh, Boon-Cher, Chang, Julie E., Durkes, Daniel, Foudray, Maria Cielo, Kantarjian, Hagop, Dong, Xiao Qin, Garcia-Manero, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901648/
https://ncbi.nlm.nih.gov/pubmed/28841236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30949
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados