Phase I Dose Escalation Multicenter Trial of Pracinostat Alone and in Combination with Azacitidine in Patients with Advanced Hematologic Malignancies

BACKGROUND: Pracinostat is a potent histone deacetylase inhibitor with antitumor activity in both solid tumor and acute myeloid leukemia (AML) cell lines. Pracinostat has modest clinical activity in advanced solid tumors. Given the higher preclinical sensitivity of hematologic malignancies to pracin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer
Egile Nagusiak: Abaza, Yasmin, Kadia, Tapan, Jabbour, Elias, Konopleva, Marina, Borthakur, Gautam, Ferrajoli, Alessandra, Estrov, Zeev, Wierda, William, Alfonso, Ana, Chong, Toh Han, Chuah, Charles, Koh, Liang-Piu, Goh, Boon-Cher, Chang, Julie E., Durkes, Daniel, Foudray, Maria Cielo, Kantarjian, Hagop, Dong, Xiao Qin, Garcia-Manero, Guillermo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901648/
https://ncbi.nlm.nih.gov/pubmed/28841236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30949
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