Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD)

Autosomal-dominant polycystic kidney disease (ADPKD) is associated with progressive formation of renal cysts, kidney enlargement, hypertension, and typically end-stage renal disease. In ADPKD, inherited mutations disrupt function of the polycystins (encoded by PKD1 and PKD2), thus causing loss of a...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Nikonova, Anna S., Deneka, Alexander Y., Kiseleva, Anna A., Korobeynikov, Vladislav, Gaponova, Anna, Serebriiskii, Ilya G., Kopp, Meghan C., Hensley, Harvey H., Seeger-Nukpezah, Tamina N., Somlo, Stefan, Proia, David A., Golemis, Erica A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901382/
https://ncbi.nlm.nih.gov/pubmed/29401581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201700909R
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