Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

PURPOSE: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on non-transformed cell populations, as extracellular ligands including Sonic Hedgehog (S...

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Bibliographic Details
Published in:Clin Cancer Res
Main Authors: Kiseleva, Anna A., Korobeynikov, Vladislav A., Nikonova, Anna S., Zhang, Peishan, Makhov, Petr, Deneka, Alexander Y., Einarson, Margret B., Serebriiskii, Ilya G., Liu, Hanqing, Peterson, Jeffrey R., Golemis, Erica A.
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606352/
https://ncbi.nlm.nih.gov/pubmed/30867219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3535
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