Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

PURPOSE: For many tumors, signaling exchanges between cancer cells and other cells in their microenvironment influence overall tumor signaling. Some of these exchanges depend on expression of the primary cilium on non-transformed cell populations, as extracellular ligands including Sonic Hedgehog (S...

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Udgivet i:Clin Cancer Res
Main Authors: Kiseleva, Anna A., Korobeynikov, Vladislav A., Nikonova, Anna S., Zhang, Peishan, Makhov, Petr, Deneka, Alexander Y., Einarson, Margret B., Serebriiskii, Ilya G., Liu, Hanqing, Peterson, Jeffrey R., Golemis, Erica A.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6606352/
https://ncbi.nlm.nih.gov/pubmed/30867219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-3535
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