Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

The mixed-lineage leukemia (MLL)-AF10 fusion oncoprotein recruits DOT1L to the homeobox A (HOXA) gene cluster through its octapeptide motif leucine zipper (OM-LZ), thereby inducing and maintaining the MLL-AF10-associated leukemogenesis. However, the recognition mechanism between DOT1L and MLL-AF10 i...

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Vydáno v:Genes Dev
Hlavní autoři: Zhang, Heng, Zhou, Bo, Qin, Su, Xu, Jing, Harding, Rachel, Tempel, Wolfram, Nayak, Vinod, Li, Yanjun, Loppnau, Peter, Dou, Yali, Min, Jinrong
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Research Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900708/
https://ncbi.nlm.nih.gov/pubmed/29563185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311639.118
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