Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

The mixed-lineage leukemia (MLL)-AF10 fusion oncoprotein recruits DOT1L to the homeobox A (HOXA) gene cluster through its octapeptide motif leucine zipper (OM-LZ), thereby inducing and maintaining the MLL-AF10-associated leukemogenesis. However, the recognition mechanism between DOT1L and MLL-AF10 i...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Zhang, Heng, Zhou, Bo, Qin, Su, Xu, Jing, Harding, Rachel, Tempel, Wolfram, Nayak, Vinod, Li, Yanjun, Loppnau, Peter, Dou, Yali, Min, Jinrong
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900708/
https://ncbi.nlm.nih.gov/pubmed/29563185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.311639.118
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