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Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1 negative human lung cancers

PURPOSE: Immunotherapy targeting the PD-1/PD-L1 pathway has changed the treatment landscape of non-small-cell lung carcinoma (NSCLC). We demonstrated that HHLA2, a newly identified immune inhibitory molecule, was widely expressed in NSCLC. We now compared the expression and function of PD-L1 with al...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Cheng, Haiying, Borczuk, Alain, Janakiram, Murali, Ren, Xiaoxin, Lin, Juan, Assal, Amer, Halmos, Balazs, Perez-Soler, Roman, Zang, Xingxing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899616/
https://ncbi.nlm.nih.gov/pubmed/29374053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2924
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