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Immune checkpoint blockade in human cancer therapy: lung cancer and hematologic malignancies

Tumor immune evasion is one of the hallmarks of cancer, and expression of the B7 family of immune checkpoints (PD-L1, PD-L2, B7-H3, B7x and HHLA2) is one mechanism of immune evasion by tumors to suppress T-cell function. Antibodies blocking these interactions of B7–1/B7–2/CTLA-4 and PD-L1/PD-L2/PD-1...

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Detalhes bibliográficos
Publicado no:Immunotherapy
Main Authors: Janakiram, Murali, Pareek, Vipul, Cheng, Haiying, Narasimhulu, Deepa M, Zang, Xingxing
Formato: Artigo
Idioma:Inglês
Publicado em: Future Medicine Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619054/
https://ncbi.nlm.nih.gov/pubmed/27349980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/imt-2016-0001
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