Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

The ability of G protein-coupled receptors (GPCRs) to initiate complex cascades of cellular signaling is governed by the sequential coupling of three main transducer proteins, G protein, GPCR kinase (GRK), and β-arrestin. Mounting evidence indicates these transducers all have distinct conformational...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Staus, Dean P., Wingler, Laura M., Choi, Minjung, Pani, Biswaranjan, Manglik, Aashish, Kruse, Andrew C., Lefkowitz, Robert J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2018
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899476/
https://ncbi.nlm.nih.gov/pubmed/29581292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722336115
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