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ATM directs DNA damage responses and proteostasis via genetically separable pathways
The protein kinase ATM is a master regulator of the DNA damage response but also responds directly to oxidative stress. Loss of ATM causes Ataxia telangiectasia, a neurodegenerative disorder with pleiotropic symptoms that include cerebellar dysfunction, cancer, diabetes, and premature aging. Here, w...
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| Publicado en: | Sci Signal |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5898228/ https://ncbi.nlm.nih.gov/pubmed/29317520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan5598 |
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