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Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM

Ataxia-Telangiectasia Mutated (ATM) regulates the DNA damage response as well as DNA double-strand break repair through homologous recombination. Here we show that ATM is hyperactive when the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is chemically inhibited or when the DNA-PKcs ge...

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Bibliografske podrobnosti
izdano v:Mol Cell
Main Authors: Zhou, Yi, Lee, Ji-Hoon, Jiang, Wenxia, Crowe, Jennie L, Zha, Shan, Paull, Tanya T.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724035/
https://ncbi.nlm.nih.gov/pubmed/27939942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.004
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