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Phosphorylation at S2053 in murine DNA-PKcs (S2056 in human) is dispensable for lymphocyte development and class switch recombination
The classical non-homologous end-joining (cNHEJ) pathway is a major DNA double-strand break repair pathway in mammalian cells and is required for lymphocyte development and maturation. The DNA-dependent protein kinase (DNA-PK) is a cNHEJ factor that encompasses the Ku70-Ku80 (KU) heterodimer and the...
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| 發表在: | J Immunol |
|---|---|
| Main Authors: | , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6581594/ https://ncbi.nlm.nih.gov/pubmed/31101667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801657 |
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