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Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency
Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, reminiscent of protein dysfunction in common neurode...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026623/ https://ncbi.nlm.nih.gov/pubmed/33571423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.01.019 |
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