MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite instable colorectal cancers

Microsatellite Instability (MSI) is displayed approximately by 15% of colorectal cancers (CRC). Defective DNA mismatch repair (MMR) generates mutations at repetitive DNA sequences such as those located in the double strand break (DSB) repair gene MRE11. We assessed the mutational status of MRE11 in...

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Autors principals: Vilar, Eduardo, Bartnik, Catherine M., Stenzel, Stephanie L., Raskin, Leon, Ahn, Jaeil, Moreno, Victor, Mukherjee, Bhramar, Iniesta, Maria D., Morgan, Meredith A., Rennert, Gad, Gruber, Stephen B.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407272/
https://ncbi.nlm.nih.gov/pubmed/21300766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-1120
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