Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic syndrome correlated with chromosomal instability and...

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Detalhes bibliográficos
Main Authors: Gaymes, Terry J., Mohamedali, Azim M., Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekararaj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney, Mufti, Ghulam J.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762096/
https://ncbi.nlm.nih.gov/pubmed/23349304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.079251
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