Microsatellite instability induced mutations in DNA repair genes CtIP and MRE11 confer hypersensitivity to poly (ADP-ribose) polymerase inhibitors in myeloid malignancies

Inactivation of the DNA mismatch repair pathway manifests as microsatellite instability, an accumulation of mutations that drives carcinogenesis. Here, we determined whether microsatellite instability in acute myeloid leukemia and myelodysplastic syndrome correlated with chromosomal instability and...

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Hauptverfasser: Gaymes, Terry J., Mohamedali, Azim M., Patterson, Miranda, Matto, Nazia, Smith, Alexander, Kulasekararaj, Austin, Chelliah, Rajani, Curtin, Nicola, Farzaneh, Farzin, Shall, Sydney, Mufti, Ghulam J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762096/
https://ncbi.nlm.nih.gov/pubmed/23349304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.079251
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