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MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2–7 and the kinase DDK. Cohesin...
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| Publicado en: | eLife |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5897099/ https://ncbi.nlm.nih.gov/pubmed/29611806 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33920 |
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