MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion

DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2–7 and the kinase DDK. Cohesin...

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Detaylı Bibliyografya
Yayımlandı:eLife
Asıl Yazarlar: Zheng, Ge, Kanchwala, Mohammed, Xing, Chao, Yu, Hongtao
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications, Ltd 2018
Konular:
Chromosomes and Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897099/
https://ncbi.nlm.nih.gov/pubmed/29611806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33920
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