IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance. We introduced th...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Noviski, Mark, Mueller, James L, Satterthwaite, Anne, Garrett-Sinha, Lee Ann, Brombacher, Frank, Zikherman, Julie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2018
Onderwerpen:
Immunology and Inflammation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897097/
https://ncbi.nlm.nih.gov/pubmed/29521626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35074
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