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IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how this could impose tolerance. We introduced th...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5897097/ https://ncbi.nlm.nih.gov/pubmed/29521626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35074 |
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