Differential Expression of IgM and IgD Discriminates Two Subpopulations of Human Circulating IgM+IgD+CD27+ B Cells That Differ Phenotypically, Functionally, and Genetically

The origin and function of blood IgM+IgD+CD27+ B cells is controversial, and they are considered a heterogeneous population. Previous staining of circulating B cells of healthy donors with rotavirus fluorescent virus-like particles allowed us to differentiate two subsets of IgM+IgD+CD27+: IgMhi and...

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Hlavní autoři: Diana Bautista, Camilo Vásquez, Paola Ayala-Ramírez, Juan Téllez-Sosa, Ernestina Godoy-Lozano, Jesús Martínez-Barnetche, Manuel Franco, Juana Angel
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-05-01
Edice:Frontiers in Immunology
Témata:
memory B cells
marginal zone B cells
cell surface molecules
cell proliferation
gene expression
Ig gene repertoire
On-line přístup:https://www.frontiersin.org/article/10.3389/fimmu.2020.00736/full
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