Preparation and in vitro/in vivo evaluation of PLGA microspheres containing norquetiapine for long-acting injection

BACKGROUND: Norquetiapine (N-desalkyl quetiapine, NQ) is an active metabolite of quetiapine with stable pharmacokinetic and pharmacological properties. However, its short half-life is a drawback for clinical applications, and long-acting formulations are required. PURPOSE: The objectives of this stu...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Park, Chun-Woong, Lee, Hyo-Jung, Oh, Dong-Won, Kang, Ji-Hyun, Han, Chang-Soo, Kim, Dong-Wook
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896679/
https://ncbi.nlm.nih.gov/pubmed/29670329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S151437
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