Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection

A novel polymeric microsphere (MS) containing micronized triamcinolone acetonide (TA) in a crystalline state was structured to provide extended drug retention in joints after intra-articular (IA) injection. Microcrystals with a median diameter of 1.7 μm were prepared by ultra-sonication method, and...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Ho, Myoung Jin, Jeong, Hoe Taek, Im, Sung Hyun, Kim, Hyung Tae, Lee, Jeong Eun, Park, Jun Soo, Cho, Ha Ra, Kim, Dong Yoon, Choi, Young Wook, Lee, Joon Woo, Choi, Yong Seok, Kang, Myung Joo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6722509/
https://ncbi.nlm.nih.gov/pubmed/31430878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11080419
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