Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions

ATP-binding cassette (ABC) transporters are transmembrane efflux transporters mediating the extrusion of an array of substrates ranging from amino acids and lipids to xenobiotics, and many therapeutic compounds, including anticancer drugs. The ABC transporters are also recognized as important contri...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Crawford, Rebecca R., Potukuchi, Praveen K., Schuetz, Erin G., Schuetz, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Special Section on Transporters in Drug Disposition and Pharmacokinetic Prediction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896366/
https://ncbi.nlm.nih.gov/pubmed/29514827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.080663
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