Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers

The hepatocyte nuclear factors, Hnf1a and Hnf4a, in addition to playing key roles in determining hepatocyte fate, have been implicated as candidate lineage-determining transcription factors in the kidney proximal tubule (PT) [Martovetsky et. al., (2012) Mol Pharmacol 84:808], implying an additional...

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Bibliographic Details
Published in:Drug Metab Dispos
Main Authors: Martovetsky, Gleb, Bush, Kevin T., Nigam, Sanjay K.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Subjects:
Special Section on Pediatric Drug Disposition and Pharmacokinetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931883/
https://ncbi.nlm.nih.gov/pubmed/27044799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.068254
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