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Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols

Nature routinely engages alcohols as leaving groups, as DNA biosynthesis relies on the removal of water from ribonucleoside diphosphates by a radical-mediated “spin-center shift” (SCS) mechanism. Alcohols, however, remain underused as alkylating agents in synthetic chemistry due to their low reactiv...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Nacsa, Eric D., MacMillan, David W. C.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5896313/
https://ncbi.nlm.nih.gov/pubmed/29400958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b12768
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