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ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response

Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evid...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Tan, Eddie Han Pin, Sng, Ming Keat, How, Ivan Shun Bo, Chan, Jeremy Soon Kiat, Chen, Jiapeng, Tan, Chek Kun, Wahli, Walter, Tan, Nguan Soon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5895604/
https://ncbi.nlm.nih.gov/pubmed/29367760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0109-8
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