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Motor neuron degeneration correlates with respiratory dysfunction in SCA1

Spinocerebellar ataxia type 1 (SCA1) is characterized by adult-onset cerebellar degeneration with attendant loss of motor coordination. Bulbar function is eventually impaired and patients typically die from an inability to clear the airway. We investigated whether motor neuron degeneration is at the...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Orengo, James P., van der Heijden, Meike E., Hao, Shuang, Tang, Jianrong, Orr, Harry T., Zoghbi, Huda Y.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894948/
https://ncbi.nlm.nih.gov/pubmed/29419414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.032623
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