Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration

Down Syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and results in a spectrum of phenotypes including learning and memory deficits, and motor dysfunction. It has been hypothesized that an additional copy of a few Hsa21 dosage-sensitive genes causes these phenotypes, but this has been ch...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Watson-Scales, Sheona, Kalmar, Bernadett, Lana-Elola, Eva, Gibbins, Dorota, La Russa, Federica, Wiseman, Frances, Williamson, Matthew, Saccon, Rachele, Slender, Amy, Olerinyova, Anna, Mahmood, Radma, Nye, Emma, Cater, Heather, Wells, Sara, Yu, Y. Eugene, Bennett, David L. H., Greensmith, Linda, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963810/
https://ncbi.nlm.nih.gov/pubmed/29746474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007383
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