Purkinje Cell Expression of a Mutant Allele of SCA1in Transgenic Mice Leads to Disparate Effects on Motor Behaviors, Followed by a Progressive Cerebellar Dysfunction and Histological Alterations

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurological disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract. Work presented here describes the behavioral and neuropathological course seen in mutant SCA1 transgenic mice. Behavioral tests indicate that at...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Neurosci
Hauptverfasser: Clark, H. Brent, Burright, Eric N., Yunis, Wael S., Larson, Seth, Wilcox, Claire, Hartman, Boyd, Matilla, Antoni, Zoghbi, Huda Y., Orr, Harry T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 1997
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573461/
https://ncbi.nlm.nih.gov/pubmed/9295384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-19-07385.1997
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge