Targeted Deletion of a Single Sca8 Ataxia Locus Allele in Mice Causes Abnormal Gait, Progressive Loss of Motor Coordination, and Purkinje Cell Dendritic Deficits

Spinocerebellar ataxia type 8 (SCA8) patients typically have a slowly progressive, adult-onset ataxia. SCA8 is dominantly inherited and is caused by large CTG repeat expansions in the untranslated antisense RNA of the Kelch-like 1 gene (KLHL1), but the molecular mechanism through which this expansio...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: He, Yungui, Zu, Tao, Benzow, Kellie A., Orr, Harry T., Clark, H. Brent, Koob, Michael D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6674467/
https://ncbi.nlm.nih.gov/pubmed/17005861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2595-06.2006
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