Purkinje Cell Expression of a Mutant Allele of SCA1in Transgenic Mice Leads to Disparate Effects on Motor Behaviors, Followed by a Progressive Cerebellar Dysfunction and Histological Alterations

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurological disorder caused by the expansion of a CAG repeat encoding a polyglutamine tract. Work presented here describes the behavioral and neuropathological course seen in mutant SCA1 transgenic mice. Behavioral tests indicate that at...

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Publicado no:J Neurosci
Main Authors: Clark, H. Brent, Burright, Eric N., Yunis, Wael S., Larson, Seth, Wilcox, Claire, Hartman, Boyd, Matilla, Antoni, Zoghbi, Huda Y., Orr, Harry T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6573461/
https://ncbi.nlm.nih.gov/pubmed/9295384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-19-07385.1997
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