Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We...

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Udgivet i:Dis Model Mech
Main Authors: Rogala, Allison R., Schoenborn, Alexi A., Fee, Brian E., Cantillana, Viviana A., Joyce, Maria J., Gharaibeh, Raad Z., Roy, Sayanty, Fodor, Anthony A., Sartor, R. Balfour, Taylor, Gregory A., Gulati, Ajay S.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894938/
https://ncbi.nlm.nih.gov/pubmed/29361512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031070
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