Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (IRGM) is an established risk allele in CD. We...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Rogala, Allison R., Schoenborn, Alexi A., Fee, Brian E., Cantillana, Viviana A., Joyce, Maria J., Gharaibeh, Raad Z., Roy, Sayanty, Fodor, Anthony A., Sartor, R. Balfour, Taylor, Gregory A., Gulati, Ajay S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5894938/
https://ncbi.nlm.nih.gov/pubmed/29361512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.031070
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