Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscor...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Taylor, Gregory A., Huang, Hsin-I, Fee, Brian E., Youssef, Nourhan, Jewell, Mark L., Cantillana, Viviana, Schoenborn, Alexi A., Rogala, Allison R., Buckley, Anne F., Feng, Carl G., Vallance, Bruce A., Gulati, Ajay S., Hammer, Gianna E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274479/
https://ncbi.nlm.nih.gov/pubmed/32453761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008553
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