Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscor...

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Détails bibliographiques
Publié dans:PLoS Pathog
Auteurs principaux: Taylor, Gregory A., Huang, Hsin-I, Fee, Brian E., Youssef, Nourhan, Jewell, Mark L., Cantillana, Viviana, Schoenborn, Alexi A., Rogala, Allison R., Buckley, Anne F., Feng, Carl G., Vallance, Bruce A., Gulati, Ajay S., Hammer, Gianna E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274479/
https://ncbi.nlm.nih.gov/pubmed/32453761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008553
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