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Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles
Helenalin is a pseudoguaianolide natural product that targets Cys38 within the DNA-binding domain of NF-κB transcription factor p65 (RelA). Helenalin contains two Michael acceptors that covalently modify cysteines, a α-methylene-γ-butyrolactone and a cyclopentenone. We recently reported two simplifi...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5894512/ https://ncbi.nlm.nih.gov/pubmed/29349898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700752 |
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