Synthesis and Antileukemic Activities of C1-C10-Modified Parthenolide Analogues

Parthenolide (PTL) is a sesquiterpene lactone natural product with anti-proliferative activity to cancer cells. Selective eradication of leukemic stem cells (LSCs) over healthy hematopoietic stem cells (HSCs) by PTL has been demonstrated in previous studies, which suggests PTL and related molecules...

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Publicado no:Bioorg Med Chem
Main Authors: Kempema, Aaron M., Widen, John C., Hexum, Joseph K., Andrews, Timothy E., Wang, Dan, Rathe, Susan K., Meece, Frederick A., Noble, Klara E., Sachs, Zohar, Largaespada, David A., Harki, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4697833/
https://ncbi.nlm.nih.gov/pubmed/26088334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.05.037
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