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Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C—H functionalization

The sesquiterpene lactone parthenolide has recently attracted considerable attention owing to its promising antitumor properties, in particular in the context of stem-cell cancers including leukemia. Yet, the lack of viable synthetic routes for reelaborating this complex natural product have represe...

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Detalhes bibliográficos
Main Authors: Kolev, Joshua N., O’Dwyer, Kristen M., Jordan, Craig T., Fasan, Rudi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904131/
https://ncbi.nlm.nih.gov/pubmed/24206617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400626w
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