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Anticancer activity profiling of parthenolide analogs generated via P450-mediated chemoenzymatic synthesis
The plant-derived sesquiterpene lactone parthenolide (PTL) was recently found to possess promising anticancer activity but elaboration of this natural product scaffold for optimization of its pharmacological properties has proven challenging via available chemical methods. In this work, P450-catalyz...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803483/ https://ncbi.nlm.nih.gov/pubmed/28826596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.08.009 |
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